Table 2.
(A) MBIC of HSGN-94 and HSGN-189 in combination with Tunicamycin against MRSA USA300 biofilms. (B) MBIC of HSGN-94 and HSGN-189 in combination with Tunicamycin against VRE ATCC 51575 biofilms. ∑FICI was calculated and interpreted as follows: ∑FICI of ≤0.5 is considered to demonstrate synergy (SYN). An ΣFICI of >0.5–1.25 was categorized as additive (ADD). ΣFICI of >1.25–4 was considered as indifference (IND), while ΣFICI values of >4 were categorized as antagonistic.
| A | MRSA USA300 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MBIC Alone | Combination MBIC | ∑FICI | SYN/ADD/IND | MBIC Alone | Combination MBIC | ∑FICI | SYN/ADD/IND | |||||
| Antibiotic | Antibiotic | HSGN-94 | Antibiotic | HSGN-94 | Antibiotic | HSGN-189 | Antibiotic | HSGN-189 | ||||
| Tunicamycin | 64 | 2 | 2 | 1 | 0.5 | SYN | 64 | 2 | 4 | 0.5 | 0.3 | SYN |
| B | VRE Faecalis ATCC 51575 | |||||||||||
| MBIC Alone | Combination MBIC | ∑FICI | SYN/ADD/IND | MBIC Alone | Combination MBIC | ∑FICI | SYN/ADD/IND | |||||
| Antibiotic | Antibiotic | HSGN-94 | Antibiotic | HSGN-94 | Antibiotic | HSGN-189 | Antibiotic | HSGN-189 | ||||
| Tunicamycin | 32 | 2 | 8 | 0.06 | 0.3 | SYN | 32 | 2 | 8 | 0.06 | 0.3 | SYN |