Table 1.

Distribution and description of the major reaction classes within the processed reaction dataset [18].

Class	Description	No. of Examples	Percentage of Dataset (%)
1	heteroatom alkylation and arylation	15122	30.3
2	acylation and related processes	11913	23.8
3	C−C bond formation	5639	11.3
4	heterocycle formation	900	1.8
5	protection	650	1.3
6	deprotection	8353	16.5
7	reduction	4585	9.2
8	oxidation	814	1.6
9	functional group interconversion (FGI)	1834	3.7
10	functional group addition (FGA)	227	0.5