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. 2020 May 25;25(10):2461. doi: 10.3390/molecules25102461

Scheme 2.

Scheme 2

Separation of racemic β2-Homo-amino acids. Reagents and conditions (i) coupling reagent TBTU, diisopropylethylamine (DIPEA), DMF, (ii) column chromatography: hexane (or CHCl3)/AcOEt, (iii) 6M HCl reflux, (iv) ion exchange chromatography (Dowex 50W-X12), NH3 aq.