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. 2020 May 14;25(10):2303. doi: 10.3390/molecules25102303

Table 1.

Affinity, molar activity and radiochemical yield (RCY) of published SV2A tracers.

Entry Tracer Ref Synthesis of the Radiotracer pIC50
for Human SV2A		 Ki (nM)
for Human SV2A		 Molar Activity (GBq. µmol−1) RCY (%)
1 [11C]Levetir-acetam [18] graphic file with name molecules-25-02303-i001.jpg 5.7 [24] 2500 17 8.3 (dc)
2 [18F]UCB-H [19] graphic file with name molecules-25-02303-i002.jpg 7.8 9.0 518 15 (ndc)
3 [21] graphic file with name molecules-25-02303-i003.jpg 815 ± 185 35 (ndc)
4 [18F]UCB-A [23] graphic file with name molecules-25-02303-i004.jpg 7.9 [24] ND a 65 14 (dc)
5 [11C]UCB-J [24] graphic file with name molecules-25-02303-i005.jpg 8.2 1.5 215 35 (dc)
6 [18F]UCB-J [27] graphic file with name molecules-25-02303-i006.jpg Similar to [11C]UCB-J Similar to [11C]UCB-J 59 ± 36 1–2 (ndc)
7 [18F]SynVesT-1 [28,29] graphic file with name molecules-25-02303-i007.jpg 8.4 2.2–4.7 b 242 19 (ndc)
8 [18F]SynVesT-2 [31] graphic file with name molecules-25-02303-i008.jpg ND a 12 141 7(dc)
9 [18F]1 [33] graphic file with name molecules-25-02303-i009.jpg 8.3 ND a 40–80 1.5 (dc)

a Unpublished information. b Respectively the value obtained by Invicro and Yale University.