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. 2020 Apr 25;9(5):1246. doi: 10.3390/jcm9051246

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of switching from EFV to RPV on the lipidomic profile. Relevant lipidomic changes grouped by chemical classes at (A) 12 weeks and at (B) 24 weeks of follow-up. Heatmap colour codes for log₂ (fold-change) and unpaired Student’s t-test p-values are indicated at the bottom of the figure. Abbreviations: AC, acyl carnitine; AS+ES (androsterone sulfate + etiocholanolone sulfate); BA, bile acid; Cer, ceramides; ChoE, cholesteryl esters; DAG, diacylglycerol; DHEAS, dehydroepianosterone sulfate; FC, fold change; HMDB, Human Metabolome Database; HODE, hydroxy-octadecadenoic acid; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; LPI, lysophosphatidylinositol; oxFA, oxidized fatty acid; PC, phosphatidylcholine; PE, Phosphatidylethanolamine; PUFA, Polyunsaturated fatty acid; SL, storage lipid; SM, sphingomyelin; ST, total steroid; TAG, triacylglycerol.