Table 1.

A comparison of age-related processes reported in sea urchins compared to similar processes in humans.

Process	Human	Sea Urchin
Mortality	Increases with age [24]	Decreased mortality with size in long-living species [23]
Regeneration/Wound Healing	Declines with age [25,26]	Maintained with age [12]
Ubiquitin-Proteasome Pathway	Decreased with age, leading to accumulation of damages and misfolded proteins [27]	Up-regulation in nerve and muscle tissues of Strongylocentrotus purpuratus [13]
Translational Regulation	Down-regulation protein synthesis machinery [28]	Components of protein synthesis machinery up-regulated with age [13]
Energy Production	Decreased expression of subunits of mitochondrial electron transport chain [29]	S. purpuratus shows no decline in energy production with age; electron transport chain and other mitochondrial genes show age-related increase in expression [13]