Table 3.
List of single nucleotide polymorphisms associated with peak oxygen uptake in the study participants. Model 1, with genetic-only influence; model 2 with covariates.
| SNP | Partial R2 | p-Value | |
|---|---|---|---|
| Model 1 | ACE rs4295 | 0.0110 | 0.0024 |
| AGTR1 rs275652 | 0.0056 | 0.0293 | |
| GDF8 rs7570532 | 0.0053 | 0.0342 | |
| Model 2 | Age | 0.2052 | <0.0001 |
| Sex | 0.1800 | <0.0001 | |
| Weight | 0.0994 | <0.0001 | |
| ACE rs4295 | 0.0063 | 0.0015 | |
| GDF8 rs7570532 | 0.0046 | 0.0058 | |
| BDKRB2 rs4144131 | 0.0037 | 0.0135 |
Abbreviation: SNP, single nucleotide polymorphism; Abbreviations for gene names: ACE, angiotensin-converting enzyme; AGTR1, angiotensin II receptor type 1; BDKRB2, bradykinin receptor B2; GDF8, growth differentiation factor 8 (also known as ‘myostatin’).