Table A1.
List of SNPs investigated for association with VO2peak (mL/kg/min) in Han Chinese untrained individuals.
| Gene | SNP | MA | MAF |
|---|---|---|---|
| ACE | rs4295 | G | 38.1 |
| ACE | rs4341 | G | 34.9 |
| ACE | rs4363 | G | 38.7 |
| ACE2 | rs6632677 | C | 9.2 |
| ACSL1 | rs10022018 | G | 24.4 |
| ACSL1 | rs11732302 | C | 24.7 |
| ACSL1 | rs12503643 | G | 45.9 |
| ACSL1 | rs12644905 | T | 19.6 |
| ACSL1 | rs13126272 | T | 11.0 |
| ACSL1 | rs1803898 | A | 7.3 |
| ACSL1 | rs2292898 | C | 7.8 |
| ACSL1 | rs13120078 | A | 8.2 |
| ACSL1 | rs2280297 | C | 47.6 |
| ACSL1 | rs2292899 | A | 38.1 |
| ACSL1 | rs3749233 | A | 25.9 |
| ACSL1 | rs3792312 | G | 41.7 |
| ACSL1 | rs4069938 | G | 37.7 |
| ACSL1 | rs6552828 | G | 35.2 |
| ACSL1 | rs902177 | C | 28.2 |
| ACTN3 | rs1815739 | T | 41.7 |
| AGT | rs10864770 | T | 34.5 |
| AGT | rs11568046 | C | 12.9 |
| AGT | rs2478523 | C | 46.0 |
| AGT | rs2478544 | C | 21.8 |
| AGT | rs2493132 | T | 37.3 |
| AGT | rs3789671 | G | 45.5 |
| AGT | rs3789678 | T | 18.7 |
| AGT | rs3889728 | A | 49.4 |
| AGT | rs5050 | G | 14.8 |
| AGT | rs6687360 | C | 33.1 |
| AGT | rs699 | T | 19.7 |
| AGT | rs7079 | A | 16.2 |
| AGT | rs7536290 | G | 22.0 |
| AGTR1 | rs2131127 | T | 37.4 |
| AGTR1 | rs275652 | C | 13.6 |
| AGTR1 | rs3772616 | A | 17.8 |
| AGTR1 | rs385338 | G | 18.0 |
| AGTR1 | rs5182 | C | 28.1 |
| AGTR1 | rs6801836 | C | 14.2 |
| BDKRB2 | rs10130005 | C | 18.3 |
| BDKRB2 | rs10132462 | T | 28.1 |
| BDKRB2 | rs11160322 | C | 23.0 |
| BDKRB2 | rs11627176 | G | 12.0 |
| BDKRB2 | rs11627761 | T | 15.3 |
| BDKRB2 | rs11848502 | T | 30.1 |
| BDKRB2 | rs12433275 | T | 16.3 |
| BDKRB2 | rs12888402 | C | 16.7 |
| BDKRB2 | rs1799722 | C | 48.0 |
| BDKRB2 | rs1959053 | T | 25.3 |
| BDKRB2 | rs2069575 | A | 20.4 |
| BDKRB2 | rs2069578 | G | 39.1 |
| BDKRB2 | rs2069586 | A | 16.5 |
| BDKRB2 | rs2069588 | T | 18.0 |
| BDKRB2 | rs2369521 | G | 35.6 |
| BDKRB2 | rs4144131 | A | 43.9 |
| BDKRB2 | rs4900315 | C | 46.5 |
| BDKRB2 | rs4900318 | A | 49.7 |
| BDKRB2 | rs4905470 | A | 20.0 |
| BDKRB2 | rs4905474 | A | 37.1 |
| BDKRB2 | rs6575577 | G | 22.5 |
| BDKRB2 | rs7155797 | T | 44.4 |
| BDKRB2 | rs7161665 | C | 47.9 |
| BDKRB2 | rs8013400 | T | 28.5 |
| BDKRB2 | rs8016905 | A | 32.7 |
| BDKRB2 | rs885818 | T | 13.4 |
| BDKRB2 | rs945039 | T | 42.9 |
| FGFR2 | rs2071616 | T | 8.8 |
| FNDC5 | rs16835198 | T | 47.7 |
| FNDC5 | rs3480 | G | 24.8 |
| FST | rs3797296 | G | 17.3 |
| FST | rs3797297 | T | 12.8 |
| FTO | rs1421085 | C | 10.4 |
| FTO | rs1558902 | A | 10.6 |
| FTO | rs9939609 | A | 10.4 |
| GDF-8 | rs16832288 | A | 19.9 |
| GDF-8 | rs7570532 | G | 26.0 |
| IL-15 | rs1057972 | A | 49.9 |
| IL-6 | rs1524107 | C | 29.3 |
| IL-6 | rs2069840 | G | 7.3 |
| IL-6 | rs2069830 | G | 27.2 |
| IL-6 | rs2069837 | G | 20.1 |
| IL-6 | rs2069852 | G | 37.0 |
| ITLN1 | rs2274906 | A | 36.5 |
| ITLN1 | rs2274910 | T | 29.6 |
| ITLN1 | rs2297560 | T | 13.9 |
| ITLN1 | rs6427552 | C | 24.7 |
| PGC-1α | rs12374310 | C | 43.9 |
| PGC-1α | rs12650562 | C | 49.5 |
| PGC-1α | rs251468 | T | 19.8 |
| PGC-1α | rs4452416 | G | 13.4 |
| PGC-1α | rs4697425 | G | 30.8 |
| PGC-1α | rs6821591 | C | 29.9 |
| PRDM16 | rs12409277 | C | 42.0 |
| PRDM16 | rs2236518 | A | 44.5 |
| PYY | rs10853114 | C | 37.8 |
| PYY | rs12953033 | A | 6.9 |
| PYY | rs162430 | G | 35.3 |
| PYY | rs1859223 | G | 27.2 |
| REN | rs11571078 | T | 12.7 |
| REN | rs1464816 | T | 24.4 |
| REN | rs2368564 | T | 20.3 |
| REN | rs4951313 | G | 29.1 |
| REN | rs5707 | G | 40.3 |
| RETN | rs3745367 | A | 35.5 |
Abbreviations: MA, minor allele; MAF, minor allele frequency; SNP, single nucleotide polymorphism; VO2peak, peak oxygen uptake. Abbreviations for gene names: ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; ACSL1, acyl-CoA synthase long-chain member 1; ACTN3, alpha-actinin-3; AGT, angiotensinogen; AGTR1, angiotensin II receptor type 1; AGTR2, angiotensin II receptor type 2; BDKRB2, bradykinin receptor B2; FGF21, Fibroblast growth factor 21; FGFR2, fibroblast growth factor receptor 2; FNDC5, fibronectin type III domain-containing protein 5; FST, follistatin; FTO, fat mass and obesity-associated protein (also known as ‘alpha-ketoglutarate-dependent dioxygenase’; GDF8, growth differentiation factor 8 (also known as ‘myostatin’); IL-6, interleukin 6; IL-15, interleukin 15; ITLN1, intelectin 1; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha; PRDM16, PR domain containing 16; PYY, peptide YY; REN, renin; RETN, resistin.