Figure 5.

Schematic representation of the well characterized human HDAC-containing core complexes. Color schemes associated with HDACs subunits refer to sequence-based classification of HDACs described in this review. The recruitment of each HDAC in the core complex is depicted schematically with grey arrows that also identifying the HDAC-binding subunit. The HDAC1/2/11-binding subunit within each complex is indicated by the purple color. In addition, each complex contains multiple DNA/chromatin binding subunits indicated in blue. Finally, other subunits, where the biological function in each complex is still uncharacterized, are indicated by the sandy color. The puzzle piece representation and orientation does not reflect specific surface interaction regions. HDAC1/2 indicates 1 or 2, interchangeably (not as a heterodimer).