Table 1.
Classification of histone deacetylases. The current manuscript will focus on ‘classical’, Zn2+-dependent HDACs.
| Family | Class (Yeast Homolog) | Subclass | Protein | Cell Compartment |
|---|---|---|---|---|
| Classical (Zn2+ dependent) | I (Rpd3) | HDAC1 | Nucleus | |
| HDAC2 | Nucleus | |||
| HDAC3 | Nucleus | |||
| HDAC8 | Nucleus | |||
| II (Hda1) | IIa | HDAC4 | Cytoplasm/Nucleus | |
| HDAC5 | Cytoplasm/Nucleus | |||
| HDAC7 | Cytoplasm/Nucleus | |||
| HDAC9 | Cytoplasm/Nucleus | |||
| IIb | HDAC6 | Cytoplasm | ||
| HDAC10 | Cytoplasm | |||
| IV (Rpd3, Hda1) | HDAC11 | Cytoplasm/Nucleus | ||
| NAD dependent | III (Sir2, Hst1-4) | SIRT 1-7 | Cytoplasm/Nucleus |