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Nogo-A mechanism of action. Nogo-A interacts with several receptors, the most important of which are NgR1, LINGO1 and p75/TROY. This interaction creates a cascade that inhibits neuroregeneration in the nerve cell growth cones. LINGO1. Leucine rich repeat and Immunoglobin-like domain-containing protein 1; p75. Neurotrophin receptor; TROY. Tumor necrosis factor receptor superfamily, member 19; RhoA. Ras homolog family member A
