TABLE 1.

Redefining Criteria for CCM

a. World Congress of Gastroenterology Criteria (2005)
Systolic Dysfunction	Diastolic Dysfunction	Supportive Criteria
Any of the following	Any of the following	• Electrophysiological abnormalities
• Blunted contractile response on stress testing	• Deceleration time >200 milliseconds	• Abnormal chronotropic response
• LV ejection fraction <55%	• Isovolumetric relaxation time >80 milliseconds	• Electromechanical uncoupling
		• Prolonged QTc interval
	• E/A <1	• Enlarged left atrium
		• Increased myocardial mass
		• Increased BNP
		• Increased proBNP
		• Increased troponin I
b. Proposed criteria by the Cirrhotic Cardiomyopathy Consortium (2019)
Systolic Dysfunction	Advanced Diastolic Dysfunction†	Areas for Future Research Which Require Further Validation
Any of the following	≥3 of the following	• Abnormal chronotropic or inotropic response§
• LV ejection fraction ≤50%	• Septal e′ velocity <7 cm/second	• Electrocardiographic changes
• Absolute* GLS <18%	• E/e′ ratio ≥15	• Electromechanical uncoupling
	• LAVI >34 mL/m2	• Myocardial mass change
	• TR velocity > 2.8 m/second‡	• Serum biomarkers
		• Chamber enlargement
		• CMRI∥

^*GLS is reported as a negative value in echocardiography reports. Changes in GLS should be described as changes in the absolute value.

^†Refer to Fig. 3 for echocardiographic changes in early diastolic dysfunction. They were not included in this table given their decreased specificity as they can occur due to aging.

^‡In the absence of evidence of primary pulmonary hypertension or portopulmonary hypertension.

^§Examples include absence of or blunted contractile or diastolic reserve on exercise stress testing, dobutamine stress testing, or at rest on CMRI.

^∥Myocardial extracellular volume as a surrogate for myocardial fibrosis can be assessed using this modality.

Abbreviation: e′, early diastolic mitral annular velocity.