Protective effect of
OP60 against APAP-induced liver injury in
mice. The serum levels of (A) AST, (B) ALT, (C) LDH, and (D) ALP were
determined in mice with APAP-induced liver injury. Data shown represent
the mean values of six mice per group ± SEM. *p < 0.05 and **p < 0.01 vs APAP-treated group.
(E) Representative images of H&E staining of liver sections from
the control group, OP60-treated (500 mg/kg) group, APAP-treated group,
and OP60 (250 and 500 mg/kg) plus APAP-treated groups (original magnification,
400×). Arrowhead: multiple and extensive areas of hepatocellular
vacuolation.