Table 1.
Demographics and Baseline Characteristics
| Characteristic | Period 1 (n = 371) | Period 2 (n = 87) | Period 3 (n = 121) | P Value |
|---|---|---|---|---|
| Age, mean ± SD, y | 64.5 ± 16.5 | 67.4 ± 16.8 | 62.9 ± 16.0 | .1 |
| Male sex, No. (%) | 233 (62.8) | 51 (58.6) | 69 (57.0) | .5 |
| Charlson comorbidity index, mean ± SD | 5.3 ± 3.0 | 5.1 ± 2.8 | 4.9 ± 2.7 | .5 |
| Pitt bacteremia score, mean ± SD | 1.3 ± 1.8 | 1.1 ± 1.5 | 1.5 ± 2.3 | .2 |
| History of IV drug abuse, No. (%) | 17 (4.6) | 3 (3.4) | 4 (3.3) | .9 |
| History of SAB, No. (%) | 48 (12.9) | 7 (8.0) | 15 (12.4) | .4 |
| Hardware or prosthetic material, No. (%) | 138 (37.2) | 27 (31.0) | 38 (31.4) | .2 |
| Community-acquired, No. (%) | 334 (90.0) | 80 (92.0) | 109 (90.0) | .9 |
| MRSA, No. (%) | 149 (40.2) | 39 (44.8) | 33 (27.3) | .02 |
| ID consult, No. (%) | 351 (94.6) | 85 (97.7) | 120 (99.2) | .05 |
| Uncomplicated bacteremia, No. (%) | 160 (43.1) | 38 (43.7) | 39 (32.2) | .09 |
| Metastatic site of infection, No. (%) | 106 (28.6) | 23 (26.4) | 47 (38.8) | .07 |
| Source of bacteremia, No. (%) | ||||
| Bone and joint | 48 (12.9) | 15 (17.2) | 26 (21.5) | .1 |
| ABSSSI | 102 (27.5) | 34 (39.1) | 32 (26.4) | |
| Respiratory | 20 (5.4) | 8 (9.2) | 6 (5.0) | |
| Endocarditis | 20 (5.4) | 1 (1.1) | 6 (5.0) | |
| Urinary | 15 (4.0) | 1 (1.1) | 3 (2.5) | |
| Intravenous catheter | 79 (21.3) | 12 (13.8) | 21 (17.4) | |
| Unknown | 53 (14.3) | 8 (9.2) | 19 (15.7) | |
| Other | 34 (9.2) | 8 (9.2) | 8 (6.6) | |
| ICU admission, No. (%) | 140 (37.7) | 25 (28.7) | 45 (37.2) | .3 |
Abbreviations: ABSSSI, acute bacterial skin and skin structure infection; ICU, intensive care unit; ID, infectious disease; IV, intravenous; MRSA, methicillin-resistant Staphylococcus aureus; SAB, Staphylococcus aureus bacteremia.