Table 3.
Primary and Secondary Outcomes
| Outcome | Period 1 (n = 371) | Period 2 (n = 87) | Period 3 (n = 121) | P Value |
|---|---|---|---|---|
| Complete bundle adherence,a No. (%) | 241 (65) | 47 (54) | 92 (76) | .004 |
| Repeat blood cultures, No. (%) | 291 (78) | 66 (76) | 105 (87) | .09 |
| Echocardiography, No. (%) | 339 (91) | 72 (83) | 121 (100) | <.0001 |
| Removal of indwelling lines or nonapplicable, No. (%) | 357 (96) | 81 (93) | 117 (97) | .4 |
| Appropriate antimicrobial therapy, No. (%) | 354 (95) | 83 (95) | 120 (99) | .1 |
| Appropriate antimicrobial duration, No. (%) | 324 (87) | 76 (87) | 112 (93) | .3 |
| Source control, No. (%) | 126 (34) | 39 (45) | 54 (45) | .04 |
| Time to IDC, mean ± SD, d | 1.06 ± 1.42 | 0.99 ± 0.85 | 0.83 ± 0.69 | .2 |
| Time to definitive therapy if change in therapy required, mean ± SD, d | 2.49 ± 1.58 | 2.41 ± 1.35 | 2.77 ± 5.67 | .7 |
| Time to blood culture clearance, mean ± SD, h | 52.6 ± 44.0 | 54.2 ± 63.3 | 41.9 ± 25.8 | .06 |
| Hospital LOS, mean ± SD, d | 10.5 ± 6.96 | 8.85 ± 6.17 | 12.0 ± 10.7 | .01 |
| ICU LOS, mean ± SD, d | 5.34 ± 6.10 | 5.33 ± 5.72 | 6.34 ± 6.28 | .6 |
| In-hospital all-cause mortality, No. (%) | 16 (4.3) | 2 (2.3) | 6 (5.0) | .6 |
| 30-d SAB-related readmission, No. (%) | 10 (2.7) | 0 (0) | 0 (0) | .07 |
Abbreviations: ICU, intensive care unit; IDC, infectious diseases consult; LOS, length of stay; SAB, Staphylococcus aureus bacteremia.
aPrimary end point.