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Trafficking of HSCs out of the bone marrow after Plerixafor administration. Plerixafor blocks the interaction between CXCR4 on the HSC and SDF‐1 in the bone marrow extracellular matrix. Source: Trajman, 2016 20. Abbreviations: HA, hyaluronan; HSC, hematopoietic stem cell; PSGL, P‐selectin glycoprotein ligand; SDF‐1, stromal cell–derived factor 1; VCAM‐1, vascular cell adhesion protein 1; VLA‐4, very late antigen 4.
