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. 2020 Jul;374(1):6–15. doi: 10.1124/jpet.119.263293

Fig. 2.

Fig. 2.

SKF 82958-induced locomotion and sensitization for male and female rats eating high fat (n = 9 male, n = 10 female) or standard chow (n = 9 male, n = 12 female). SKF 82958-induced locomotion (e.g., ambulatory counts) for the last 5 minutes of each 15-minute recording session after 5 weeks of initial assignment to dietary conditions (A and B). Area under the weekly generated SKF 82958 dose-response curves (AUC) for male and female rats eating high fat or standard chow for 1–6 weeks (C and D). Three female rats eating high fat chow were lost due to attrition: two during week 4 and one during week 5 (data not included in analysis). Data were analyzed using a three-way (sex × diet × dose) mixed model ANOVA with Sidak’s multiple comparison post hoc tests. Data are expressed as means ± S.E.M. *P < 0.05, dietary difference within sex; #P < 0.05, female rats eating high fat chow had significantly increased locomotion compared with all other groups.