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. 2020 May 26;12(10):9549–9584. doi: 10.18632/aging.103227

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Copyright © 2020 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Differential expression of miRNA and mRNA. (A) Heat map of Differentially expressed micro-RNAs from GSE70318. (B) Heat map of Differentially expressed mRNAs from GSE25462. Red: upregulation; Blue: downregulation. GSE70318 provides information on serum miRNA signals regarding fractures in postmenopausal women with or without type 2 diabetes. GSE25462 is a dataset of miRNAs related to diabetes and skeletal muscle insulin resistance. We did not find a miRNA dataset directly related to diabetic skeletal disease; considering the close relationship between skeletal muscle and bone (especially fracture risk), and the large size and high quality of the GSE25462 dataset, we used these data.