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. 2020 May 27;12(10):9948–9958. doi: 10.18632/aging.103260

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Copyright © 2020 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Down-regulation of TopBP1 significantly suppressed the proliferation of both 22RV1 (A) and LNCaP (B, C) qRT-PCR was performed to detect alteration of the TopBP1 expression. (D) Western blotting was performed to detect alteration of TopBP1. (E–H) Down-regulation of TopBP1 suppresses the migration of prostate cancer. (E, G) Represented images of two separated experiments in each cell line are showed. The data presented are mean ± SD for three independent experiments. **P<0.01 compared with NC, ***P<0.001 compared with NC.