Figure 2.

Pathway analysis found four significant differential metabolic pathways. Using nuclear magnetic resonance (NMR) metabolomics analysis, the increase of glucose uptake in PH rats, the accumulation of various glycolysis products such as lactic acid, and the activation of glycolytic pathway in PH rats were observed. This data indicated that there was a phenomenon in vascular cell proliferation and energy metabolism in PH rats. (1. Glycolytic pathway, 2. Arginine and proline metabolic pathway, 3. Butyric acid metabolic pathway, 4. Glycine, serine and threonine metabolism.)