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. 2020 May 19;12(10):9292–9310. doi: 10.18632/aging.103206

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Copyright © 2020 Chang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The expression levels of key piRNAs were corrected by demographic data to construct a multivariate model to distinguish malignant nodules from benign. (A) Nomogram based on multivariate model (A). The calibration curve and ROC curves suggested acceptable calibration (B) and discrimination (C) of the nomogram, respectively. Additionally, piR-13643 (P < 0.001), piR-21238 (P = 0.061) and HBME1 (P = 0.009) were higher in malignant nodules compared to benign nodules in both fresh and paraffin samples (D–F).