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. 2020 May 15;12(10):9633–9657. doi: 10.18632/aging.103233

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Copyright © 2020 Zhou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MiR-214-3p suppresses CRC cell metastasis in vitro and in vivo. (A–C) Transwell assays revealed that miR-214-3p suppressed CRC cell migration and invasion abilities. (D–E) Western blot analysis revealed that miR-214-3p decreased the expression of N-cadherin and vimentin and increased the expression of E-cadherin and Zo1. (F–I) More lung metastatic nodules were observed in the LV-miR-214-3p group than in the LV-INC group. (J–K) IHC analysis indicated that the expression of E-cadherin was lower and that the expression of N-cadherin was higher in xenograft subcutaneous tissues from the LV-miR-214-3p inhibitor group. The data are represented as the means±S.D. from at least three independent experiments. *p<0.05.