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. 2020 May 18;12(10):9205–9223. doi: 10.18632/aging.103192

Table 3. Functional roles of 20 hub genes.

No. Gene symbol Full name Function
1 VCAN Versican Pathways: chondroitin sulfate/dermatan sulfate metabolism and diseases of glycosylation. GO: calcium ion binding and extracellular matrix structural constituent
2 CAV1 Caveolin 1 Pathways: Focal Adhesion and TNF signaling (REACTOME). GO: identical protein binding and signaling receptor binding.
3 EPCAM Epithelial Cell Adhesion Molecule Pathways: Cell surface interactions at the vascular wall and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
4 EGF Epidermal Growth Factor Pathways: Gastric cancer and Vesicle-mediated transport. GO: calcium ion binding and epidermal growth factor receptor binding.
5. GPC3 Glypican 3 Pathways: Chondroitin sulfate/dermatan sulfate metabolism and Metabolism of fat-soluble vitamins. GO: heparan sulfate proteoglycan binding and peptidyl-dipeptidase inhibitor activity.
6 CCL5 C-C Motif Chemokine Ligand 5 Pathways: PEDF Induced Signaling and Innate Immune System. GO: protein homodimerization activity and chemokine activity.
7 CSF1R Colony Stimulating Factor 1 Receptor Pathways: GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO: protein homodimerization activity and protein kinase activity.
8 TIMP1 TIMP Metallopeptidase Inhibitor 1 Pathways: GPCR Pathway and Matrix Metalloproteinases. GO: cytokine activity and protease binding.
9 COL1A1 Collagen Type I Alpha 1 Chain Pathways: IL4-mediated signaling events and Integrin Pathway. GO: identical protein binding and platelet-derived growth factor binding.
10 DCN Decorin Pathways: Chondroitin sulfate/dermatan sulfate metabolism and Diseases of glycosylation. GO: collagen binding.
11 VEGFA Vascular Endothelial Growth Factor A Pathways: VEGF Signaling Pathway and Bladder cancer. GO: protein homodimerization activity and protein heterodimerization activity.
12 KNG1 Kininogen 1 Pathways: Collagen chain trimerization and amb2 Integrin signaling. GO: signaling receptor binding and cysteine-type endopeptidase inhibitor activity.
13 ITGB1 Integrin Subunit Beta 2 Pathways: Activated TLR4 signalling and Focal Adhesion. GO: protein heterodimerization activity.
14 IGFBP3 Insulin Like Growth Factor Binding Protein 3 Pathways: TP53 Regulates Transcription of Cell Death Genes and Celecoxib Pathway, Pharmacodynamics. GO: fibronectin binding and insulin-like growth factor I binding.
15 ALB Albumin Pathways: Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) and Synthesis of bile acids and bile salts. GO: enzyme binding and chaperone binding.
16 CD163 CD163 Molecule Pathways: Binding and Uptake of Ligands by Scavenger Receptors and Dendritic Cells Developmental Lineage Pathway. GO: scavenger receptor activity.
17 CASR Calcium Sensing Receptor Pathways: Parathyroid hormone synthesis, secretion and action and E-cadherin signaling in keratinocytes. GO: G protein-coupled receptor activity and protein kinase binding.
18 ITGA5 Integrin Subunit Alpha 5 Pathways: Cell surface interactions at the vascular wall and Focal Adhesion. GO: integrin binding and epidermal growth factor receptor binding.
19 AQP2 Aquaporin 2 Pathways: Aquaporin-mediated transport and Glucose / Energy Metabolism. GO: actin binding and PDZ domain binding.
20 SLC12A1 Solute Carrier Family 12 Member 1 Pathways: Neuroscience and Diuretics Pathway, Pharmacodynamics. GO: transporter activity and sodium:potassium:chloride symporter activity.