. Author manuscript; available in PMC: 2021 May 1.

Published in final edited form as: Ann Neurol. 2020 Feb 27;87(5):700–709. doi: 10.1002/ana.25702

TABLE 2.

Change in Overnight (01:00–11:00) Cerebrospinal Fluid Tau and Phosphorylated Tau from Baseline

Site	Factor	Pairwise Comparison	Estimated Difference, % (95% CI)	F (df )	p
T181	Intervention			16.6 (2, 99)	<0.0001^a
		Sleep-deprived vs control	+33.04 (+15.9 to +50.2)		<0.0001^a,b
		Sleep-deprived vs drug	+38.48 (+20.3 to +56.6)		<0.0001^a,b
		Control vs drug	+5.44 (−12.7 to +23.6)		1.0^b
pT181	Intervention			18.3 (2, 99)	<0.0001^a
		Sleep-deprived vs control	+41.9 (+20.8 to +63.0)		<0.0001^a,b
		Sleep-deprived vs drug	+50.3 (+28.0 to +72.6)		<0.0001^a,b
		Control vs drug	+8.4 (−13.9 to +30.7)		1.0^b
pT181/T181	Intervention			2.89 (2, 102)	0.06
		Sleep-deprived vs control	+4.16 (−0.80 to +9.1)		0.131^b
		Sleep-deprived vs drug	+4.47 (−0.74 to +5.5)		0.118^b
		Control vs drug	+0.31 (−4.9 to +5.5)		1.0^b
S202	Intervention			18.98 (2, 99)	<0.0001^a
		Sleep-deprived vs control	+37.73 (+20.0 to +55.4)		<0.0001^a,b
		Sleep-deprived vs drug	+41.38 (+22.6 to +60.2)		<0.0001^a,b
		Control vs drug	+3.65 (−15.1 to +22.4)		1.0^b
pS202	Intervention			4.79 (2, 99)	0.01
		Sleep-deprived vs control	+10.1 (−1.6 to +21.8)		0.112^b
		Sleep-deprived vs drug	+15.06 (+2.8 to +27.3)		0.01^a,b
		Control vs drug	+4.96 (−7.3 to +17.2)		0.981^b
pS202/S202	Intervention			6.3 (2, 98)	0.003^a
		Sleep-deprived vs control	−14.19 (−23.9 to −4.5)		0.002^a,b
		Sleep-deprived vs drug	−7.35 (−17.6 to +2.9)		0.254^b
		Control vs drug	+6.85 (−3.4 to +17.1)		0.324^b
T217	Intervention			23.2 (2, 98)	<0.0001^a
		Sleep-deprived vs control	+37.42 (+19.8 to +55.1)		<0.0001^a,b
		Sleep-deprived vs drug	+48.72 (+30.0 to +67.4)		<0.0001^a,b
		Control vs drug	+11.31 (−7.4 to +30.0)		0.433^b
pT217	Intervention			33.82 (2, 98)	<0.0001^a
		Sleep-deprived vs control	+64.33 (+39.7 to +89.0)		<0.0001^a,b
		Sleep-deprived vs drug	+81.52 (+55.4 to +107.7)		<0.0001^a,b
		Control vs drug	+17.19 (−9.0 to +43.3)		0.338^a
pT217/T217	Intervention			19.3 (2, 100)	<0.0001^a
		Sleep-deprived vs control	+16.84 (+8.7 to +25.0)		<0.0001^a,b
		Sleep-deprived vs drug	+19.66 (+11.1 to +28.2)		<0.0001^a,b
		Control vs drug	+2.83 (−5.8 to +11.4)		1.0^b

Statistically significant.

Bonferroni corrected for multiple comparisons.

CI = confidence interval; df = degrees of freedom; pS202 = phosphorylated serine 202; pT181 = phosphorylated threonine 181; pT217 = phosphorylated threonine 217; S202 = serine 202; T181 = threonine 181; T217 = threonine 217.