Fig. 3.
A schematic of mitochondrial CI assembly. An initiating assembly intermediate consisting of NDUFS2 and NDUFS3 combines with NDUFS7 and NDUFS8 to ultimately form the Q module. The Q module is anchored to the membrane by combining with subunits that are part of the proximal part of the P module (PP). The Q + PP module combines with the distal part of the P module (PD) to form an assembly intermediate consisting of the complete Q + P modules. Finally, the assembly intermediate consisting of the Q + P modules associates with the independently formed N module to form the fully assembled CI