Fig. 1.

SARS-CoV-2 nsp7-nsp8 complex crystal structure A - Schematic representation of the crystallized and wild-type proteins. B - The overall view of the putative 2:2 nsp7-nsp8 heterotetrameric complex. A detailed view of the tetrameric interface between the nsp7 and nsp8 proteins is shown. C - A detailed view of the nsp7-nsp8 dimer with the dimeric interface highlighted. The protein backbones are shown in cartoon representation; the nsp7 and nsp8 proteins are depicted in blue and yellow, respectively. Selected amino acid residues involved in the nsp7-nsp8 interaction are presented in the stick representation with carbon atoms colored according to the protein assignment. D - Topology plot of the nsp7-nsp8 protein complex. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)