Figure 8.

a, b. DF-MSCs modulated cytokine levels in the supernatants of lymphocyte. Isolated cells collected from patients’ inflamed and noninflamed biopsies were cultured in a 96-well plate following CDmix stimulation in the presence or absence of MSCs. The levels of cytokines in the supernatants of lymphocytes were determined using flow cytometry. DF-MSCs significantly decreased TNF-α (a), IL-6 (b), and IFN-γ (c) but significantly increase IL-10 (d) levels in inflamed culture. MSCs significantly decreased IL-6 (B) in noninflamed culture (p<0.01). IL-4 did not show significant difference in the presence of MSCs. *p<0.05, **p<0.01, Results are shown as mean±SD. DF-MSCs referred as MSCs.