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I‐SPY 2 study schema and adaptive randomization. Patients were randomized to the control (paclitaxel for HER2− or paclitaxel + trastuzumab for HER2+) or one of the experimental drug arms. Participants received a weekly dose of paclitaxel alone (control) or in combination with an experimental agent for 12 weekly cycles followed by 4 (every 2–3 weeks) cycles of anthracycline–cyclophosphamide (AC) before surgery.
