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. 2009 Aug 21;18(23):4478–4491. doi: 10.1093/hmg/ddp407

Figure 6.

Figure 6.

Cell migration depends on Ocrl1 but not on Inpp5b functional status. (A) Normal and LS fibroblasts transfected with the indicated cDNAs were assayed for migration in transwells as described under Materials and Methods. Values represent the mean ± SD of at least three independent determinations. Statistical significance was estimated using pairedt-tests with a correction for significant threshold according to the number of test performed (α = 0.05/3 = 0.017). **P < 0.017. (B) HeLa cells were knocked-down using siRNA against human Ocrl1 and Inpp5b, respectively, or mock-treated. Cells were assayed for migration in transwells as described under Materials and Methods. Values represent the mean ± SD of at least three independent determinations. Statistical significance was estimated using pairedt-tests with a correction for significant threshold according to the number of test performed (α = 0.05/2 = 0.025). **P < 0.025. Knock-down efficiency was controlled by western blotting with specific antibodies. Tubulin was used as loading control.