Table 5.
Biochemical parameters and inflammatory cytokines of survivors and non-survivors with COVID-19.
| N | Total | Alive | Died | P value | |
|---|---|---|---|---|---|
| CRP, mg/L (<8) | |||||
| Baseline | 1046 | 11 (3, 44) | 9 (3, 30) | 93 (58, 125) | <0.001 |
| Max | 1063 | 14 (4, 55) | 11 (3, 38) | 140 (110, 181) | <0.001 |
| Procalcitonin, ng/ml (<0.5) | |||||
| Baseline | 1273 | 0.05 (0.05, 0.1) | 0.05 (0.04, 0.1) | 0.2 (0.12, 0.6) | <0.001 |
| Max | 1065 | 0.07 (0.04, 0.1) | 0.06 (0.04, 0.1) | 1.2 (0.4, 4) | <0.001 |
| LDH, U/L (109–245) | |||||
| Baseline | 1338 | 207 (165, 283) | 199 (161, 258) | 470 (359, 599) | <0.001 |
| Max | 1354 | 215 (174, 302) | 207 (169, 271) | 707 (509, 1154) | <0.001 |
| Ferritin, ng/ml (4.6–204) | 231 | 542 (226, 1207) | 446 (191, 906) | 1584 (1196, 2000) | <0.001 |
| ALT, U/L (5–35) | 1429 | 39 (22, 68) | 37 (21, 66) | 62 (34, 150) | <0.001 |
| AST, U/L (8–40) | 1428 | 31 (22, 49) | 30 (22, 44) | 68 (45, 143) | <0.001 |
| Total bilirubin, μmol/L (5.1–19) | 1245 | 14 (10, 19) | 13 (10, 17) | 25 (16, 39) | <0.001 |
| Creatine kinase, U/L (26–140) | 1151 | 87 (54, 150) | 81 (52, 130) | 253 (104, 656) | <0.001 |
| BNP, pg/ml (<100) | 627 | 50 (14, 160) | 39 (12, 115) | 454 (116, 1377) | <0.001 |
| Myoglobin, ng/ml (<140) | 718 | 32 (21, 60) | 29 (21, 49) | 476 (147, 1200) | <0.001 |
| Troponin I, ng/L (<26.2) | 830 | 3 (1, 10) | 2 (0.9, 7) | 212 (48, 1011) | <0.001 |
| BUN, mmol/L (2.9–8.2) | 1414 | 5 (4, 6) | 5 (4, 6) | 14 (8, 23) | <0.001 |
| Scr, μmol/L (44–106) | 1414 | 70 (59, 83) | 69 (59, 81) | 100 (71, 211) | <0.001 |
| IL-2, pg/ml (0.1–4.1) | 344 | 3 (3, 4) | 3 (3, 4) | 3 (3, 5) | 0.849 |
| IL-4, pg/ml (0.1–3.2) | 380 | 3 (2, 4) | 3 (2, 4) | 2 (2, 4) | 0.804 |
| IL-6, pg/ml (0.1–2.9) | 659 | 10 (4, 37) | 9 (4, 30) | 71 (29, 442) | <0.001 |
| IL-10, pg/ml (0.1–5) | 380 | 4 (3, 6) | 4 (3, 5) | 11 (6, 30) | <0.001 |
| TNF α, pg/ml (0.1–23) | 380 | 3 (2, 6) | 4 (2, 6) | 3 (2, 4) | 0.183 |
| IFN γ, pg/ml (0.1–18) | 380 | 3 (2, 4) | 3 (2, 4) | 3 (2, 4) | 0.88 |
CRP C-reactive protein, LDH lactate dehydrogenase, ALT alanine aminotransferase, AST aspartate aminotransferase, BNP brain natriuretic peptide, BUN blood urea nitrogen, Scr serum creatinine, IL interleukin, TNF tumor necrosis factor, IFN interferon.