Fig 5. APOE2 genotype protects against motor deficits and prolongs survival in A53T mice.
(A) Assessment of motor function in A53T mice. Latency to fall in the inverted wire screen test was measured for A53T/EKO (n=24), A53T/E2 (n=28), A53T/E3 (n=8), and A53T/E4 (n=22) mice. (B) Kaplan-Meier survival analysis of A53T mice by APOE genotype for A53T/EKO (n=10, median survival 11.6 months), A53T/E2 (n=7, median survival 18.4 months), A53T/E3 (n=5, median survival 12.7 months), A53T/E4 (n=18, median survival 11.7 months) mice. Overall log-rank (Mantel-Cox) p=0.0030.