Table 1. Multivariate regression analysis of rate of change of MoCA scores over time in PPMI participants.
Covariates included age at onset of PD (Age at Onset), age at baseline MoCA test (Age at Baseline), sex, years of education (Education), baseline MoCA score (Baseline MoCA), principal component analysis of genetic ancestry (PC1–4), APOE genotype, last available CSF Aβ42, tau, and αSyn concentrations, and the time interval between MoCA assessments. Interaction of covariates with the rate of change of MoCA score over time are listed as “Covariate : Time.” Data are presented as beta coefficients with 95% confidence interval and p-value, after accounting for the effect of covariates.
| Variable | Beta | 95% CI | p-value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Age at Onset | −5.22E−02 | −1.46E−01 | 4.15E−02 | 2.79E−01 |
| Age at Baseline | −1.20E−02 | −8.28E−02 | 1.07E−01 | 8.06E−01 |
| Sex | 3.81E−01 | 5.04E−02 | 7.07E−01 | 2.39E−02 |
| Education | 1.45E−02 | −4.02E−02 | 6.98E−02 | 6.07E−01 |
| Baseline MoCA | 6.29E−01 | 5.11E−01 | 7.49E−01 | 1.20E−22 |
| PC1 | −1.45E+02 | −4.35E+02 | 1.46E+02 | 3.33E−01 |
| PC2 | −1.07E+01 | −1.87E+02 | 1.62E+02 | 9.04E−01 |
| PC3 | −9.10E+00 | −2.47E+01 | 6.52E+00 | 2.57E−01 |
| PC4 | 1.18E+01 | −2.26E+01 | 4.62E+01 | 5.05E−01 |
| APOE ε2 | 4.34E−02 | −3.92E−01 | 4.84E−01 | 8.47E−01 |
| APOE ε4 | −3.51E−02 | −4.07E−01 | 3.32E−01 | 8.53E−01 |
| CSF Aβ42 | −6.70E−05 | −5.76E−04 | 4.45E−04 | 7.98E−01 |
| CSF pTau | 2.23E−03 | −3.18E−02 | 3.58E−02 | 8.98E−01 |
| CSF αSyn | −6.61E−02 | −3.27E−01 | 1.89E−01 | 6.18E−01 |
| Time Interval | 5.78E−02 | −2.03E+00 | 2.15E+00 | 9.58E−01 |
| Age at onset : Time | 1.63E−02 | −2.75E−02 | 6.06E−02 | 4.80E−01 |
| Age at baseline : Time | −2.91E−02 | −7.39E−02 | 1.52E−02 | 2.14E−01 |
| Sex : Time | −8.07E−02 | −2.30E−01 | 7.21E−02 | 3.09E−01 |
| Education : Time | 2.99E−02 | 4.60E−03 | 5.48E−02 | 2.40E−02 |
| Baseline MoCA : Time | −3.24E−02 | −8.69E−02 | 2.11E−02 | 2.54E−01 |
| PC1 : Time | −1.05E+02 | −2.36E+02 | 2.52E+01 | 1.27E−01 |
| PC2 : Time | −7.63E+00 | −8.61E+01 | 7.28E+01 | 8.54E−01 |
| PC3 : Time | −5.18E+00 | −1.20E+01 | 1.64E+00 | 1.51E−01 |
| PC4 : Time | 4.55E+00 | −1.09E+01 | 2.01E+01 | 5.78E−01 |
| APOE ε2 : Time | −4.02E−02 | −2.41E−01 | 1.57E−01 | 7.00E−01 |
| APOE ε4 : Time | −2.26E−01 | −3.95E−01 | −5.43E−02 | 1.19E−02 |
| CSF Aβ42 : Time | 5.19E−04 | 2.81E−04 | 7.57E−04 | 4.77E−05 |
| CSF pTau : Time | −3.85E−02 | −5.43E−02 | −2.27E−02 | 5.87E−06 |
| CSF αSyn : Time | −4.42E−02 | −1.63E−01 | 7.69E−02 | 4.82E−01 |
| APOE2 Count | 0 | 1 | 2 | |
| Number of Individuals: | 217 | 31 | 3 | |
| APOE4 Count | 0 | 1 | 2 | |
| Number of Individuals: | 182 | 61 | 8 | |