Figure. 1.

Correlations between components of the duodenal proteome, the absolute abundances of duodenal bacterial taxa and stunting.

(A) The top 10 positive correlations between members of the 14 core taxa and duodenal proteins. The size and color of the circle represents the magnitude of the correlation (larger circle and darker color indicates stronger correlation). (B) Annotations of proteins shown in panels A and G. (C-F) Total duodenal bacterial load, and the abundances of the three organisms most positively correlated with duodenal inflammatory proteins are significantly negatively correlated with LAZ. The least-squares regression line is depicted in blue while shaded regions denote 95% confidence bands. (G) Star network of correlations between plasma REG3A and core taxa-associated duodenal proteins. As indicated by the color key, edge transparency/color corresponds to correlation strength (darker edges denote a stronger correlation). The duodenal protein with the strongest correlation, lipocalin-2 (LCN-2), is indicated by the tail of the arrowhead at 3 o’clock; duodenal proteins with progressively weaker correlations with REG3A are distributed in a counter-clockwise fashion from this position.