| Correlations between features of the duodenal microbiota and LAZ (n=36 children) | |||||
|---|---|---|---|---|---|
| Pearson ρ | Coefficient (95% CI)*† | p-value | FDR-adjusted q-value | Mean relative abundance (95% CI)* | |
| Streptococcus sp. | -0.40 | -0.31 (-0.54, -0.07) | 0.02 | 0.10 | 45.2% (38.3%, 52.2%) |
| Gemella sp. | -0.38 | -0.33 (-0.61, -0.06) | 0.02 | 0.10 | 8.43% (5.82%, 11.04%) |
| Neisseria subflava | -0.41 | -0.20 (-0.35, -0.05) | 0.01 | 0.10 | 6.37% (4.04%, 8.71%) |
| Haemophilus sp. | -0.39 | -0.20 (-0.37, -0.04) | 0.02 | 0.10 | 8.02% (4.28%, 11.76%) |
| Granulicatella elegans | -0.47 | -0.38 (-0.62, -0.13) | 0.004 | 0.04 | 5.56% (4.29%, 6.82%) |
| Veilonella sp. | -0.44 | -0.32 (-0.54, -0.10) | 0.007 | 0.06 | 0.79% (0.57%, 1.00%) |
| Rothia mucilaginosa | -0.45 | -0.31 (-0.53, -0.10) | 0.006 | 0.06 | 2.37% (1.30%, 3.43%) |
| Actinomyces sp. | -0.37 | -0.29 (-0.53, -0.04) | 0.03 | 0.10 | 0.44% (0.33%, 0.54%) |
| Leptotrichia sp. | -0.49 | -0.28 (-0.46, -0.11) | 0.003 | 0.04 | 2.38% (1.45%, 3.32%) |
| Prevotella melaninogenica | -0.48 | -0.28 (-0.45, -0.10) | 0.003 | 0.04 | 1.55% (0.73%, 2.36%) |
| Fusobacterium sp. | -0.48 | -0.27 (-0.44, -0.10) | 0.003 | 0.04 | 0.92% (0.55%, 1.29%) |
| Leptotrichia shahii | -0.50 | -0.35 (-0.56, -0.14) | 0.002 | 0.03 | 0.46% (0.14%, 0.78%) |
| Corynebacterium sp. | -0.32 | -0.22 (-0.45, 0.00) | 0.06 | 0.10 | 0.18% (0.11%, 0.25%) |
| Johnsonella sp. | -0.36 | -0.26 (-0.50, -0.03) | 0.03 | 0.10 | 0.24% (0.14%, 0.33%) |
| Total bacterial load‡ | -0.41 | -0.32 (-0.56, -0.08) | 0.01 | 0.10 | 33.0 (2.67, 63.3) |
| Total bacterial load of 'core group' taxa§ | -0.49 | -0.38 (-0.61, -0.15) | 0.003 | 0.04 | 38.9 (34.1, 43.8) |
CI denotes 95% confidence interval
Fecal biomarkers, plasma proteins, total bacterial load, and abundances of duodenal bacterial taxa were log-transformed and z-scored prior to determining their relationships with LAZ. Thus, coefficients represent the effect of a unit change in standard deviation of the independent variable on the dependent variable. Fecal biomarker concentrations are reported as their measured concentrations, prior to log-transformation or z-scoring.
Total bacterial load represents the inverse of the fractional abundance of the A. acidophilus spike-in.
Total bacterial load of core group taxa represents the summed absolute abundances of the 14 bacterial ASVs found in > 80% of duodenal aspirates at a relative abundance of >0.01%.