Table 2. Significantly differentially expressed miRNAs (FDR ≤ 0.05) in LN+ vs. LN0 primary tumors of the Discovery cohort.
| miRNA name and accession | P | FDR | Log2 FC |
|---|---|---|---|
| Down-regulated | |||
| hsa-mir-375. MIMAT0000728 | 3.05E-03 | 0.026 | –2.06 |
| hsa-mir-203a. MIMAT0000264 | 3.15E-04 | 0.008 | –1.76 |
| hsa-mir-3065. MIMAT0015378 | 5.07E-03 | 0.034 | –1.01 |
| hsa-mir-944. MIMAT0004987 | 2.22E-03 | 0.025 | –0.89 |
| hsa-let-7c. MIMAT0026472 | 7.66E-03 | 0.047 | –0.73 |
| hsa-mir-125b-2. MIMAT0004603 | 1.52E-03 | 0.018 | –0.71 |
| hsa-mir-200c. MIMAT0000617 | 2.97E-04 | 0.008 | –0.70 |
| hsa-mir-200b. MIMAT0000318 | 3.65E-03 | 0.030 | –0.60 |
| hsa-mir-139. MIMAT0004552 | 5.77E-04 | 0.011 | –0.59 |
| hsa-mir-23b. MIMAT0000418 | 9.69E-05 | 0.005 | –0.58 |
| hsa-mir-139. MIMAT0000250 | 1.22E-03 | 0.016 | –0.58 |
| hsa-mir-200c. MIMAT0004657 | 6.63E-03 | 0.042 | –0.57 |
| hsa-mir-744. MIMAT0004945 | 9.18E-04 | 0.013 | –0.51 |
| hsa-mir-378a. MIMAT0000732 | 2.46E-04 | 0.008 | –0.44 |
| hsa-mir-500a. MIMAT0002871 | 1.15E-03 | 0.016 | –0.42 |
| hsa-mir-501. MIMAT0004774 | 2.90E-03 | 0.026 | –0.37 |
| hsa-mir-30d. MIMAT0000245 | 2.47E-03 | 0.026 | –0.33 |
| hsa-mir-532. MIMAT0002888 | 7.29E-04 | 0.012 | –0.31 |
| hsa-mir-23a. MIMAT0000078 | 2.90E-03 | 0.026 | –0.28 |
| hsa-mir-660. MIMAT0003338 | 4.59E-03 | 0.032 | –0.27 |
| hsa-mir-423. MIMAT0001340 | 3.75E-03 | 0.030 | –0.15 |
| Up-regulated | |||
| hsa-mir-28. MIMAT0000085 | 2.41E-03 | 0.026 | 0.33 |
| hsa-mir-21. MIMAT0004494 | 2.90E-03 | 0.026 | 0.41 |
| hsa-mir-26a. MIMAT0000082 | 6.32E-03 | 0.040 | 0.41 |
| hsa-mir-3607. MIMAT0017985 | 4.25E-03 | 0.032 | 0.45 |
| hsa-mir-106b. MIMAT0000680 | 2.54E-04 | 0.008 | 0.45 |
| hsa-mir-339. MIMAT0000764 | 2.90E-03 | 0.026 | 0.47 |
| hsa-mir-155. MIMAT0000646 | 3.56E-03 | 0.030 | 0.51 |
| hsa-mir-181a-2. MIMAT0004558 | 3.94E-03 | 0.030 | 0.52 |
| hsa-mir-330. MIMAT0004693 | 5.20E-03 | 0.034 | 0.52 |
| hsa-mir-181a-1. MIMAT0000270 | 6.49E-04 | 0.011 | 0.53 |
| hsa-mir-3613. MIMAT0017990 | 1.91E-04 | 0.007 | 0.53 |
| hsa-mir-214. MIMAT0004564 | 5.20E-03 | 0.034 | 0.58 |
| hsa-mir-199a. MIMAT0000232 | 4.47E-03 | 0.032 | 0.62 |
| hsa-let-7i. MIMAT0004585 | 1.26E-04 | 0.005 | 0.62 |
| hsa-mir-199b. MIMAT0004563 | 4.36E-03 | 0.032 | 0.62 |
| hsa-mir-16. MIMAT0000069 | 1.25E-03 | 0.016 | 0.64 |
| hsa-mir-29a. MIMAT0000086 | 3.05E-03 | 0.026 | 0.65 |
| hsa-mir-342. MIMAT0004694 | 4.41E-04 | 0.009 | 0.66 |
| hsa-mir-106a. MIMAT0000103 | 7.73E-04 | 0.012 | 0.70 |
| hsa-mir-146b. MIMAT0002809 | 3.46E-04 | 0.008 | 0.70 |
| hsa-mir-22. MIMAT0004495 | 2.22E-03 | 0.025 | 0.75 |
| hsa-mir-342. MIMAT0000753 | 7.08E-04 | 0.012 | 0.77 |
| hsa-mir-21. MIMAT0000076 | 3.44E-07 | 0.000 | 0.78 |
| hsa-mir-181b-1. MIMAT0022692 | 5.12E-05 | 0.003 | 0.80 |
| hsa-mir-146b. MIMAT0004766 | 3.15E-05 | 0.002 | 0.88 |
| hsa-mir-32. MIMAT0000090 | 3.20E-06 | 0.000 | 1.12 |
| hsa-mir-142. MIMAT0000433 | 5.77E-04 | 0.011 | 1.17 |
| hsa-mir-107. MIMAT0000104 | 9.70E-07 | 0.000 | 2.72 |
Abbreviation(s): FDR, false discovery rate; FC, fold change.