Table 1.
Characteristics of children with febrile neutropenia and acute lymphoblastic leukemia infected with SARS-CoV-2
| Reference range | Patient 1 | Patient 2 | Patient 3 | |
|---|---|---|---|---|
| Age (years) | 9 | 4 | 8 | |
| Sex | Fem | Fem | Fem | |
| Medical history | ||||
| Conditions | ALL in consolidation therapy | ALL in consolidation therapy | ALL post-hematopoietic stem cells transplantation | |
| Medicaments | Cytarabine and cyclophosphamide | Methotrexate and mercaptopurine | Mycophenolate, prednisone | |
| Values on admission | ||||
| White cell count (per mm3) | 1000 | 920 | 1300 | |
| Neutrophils (per mm3) | 150 | 350 | 475 | |
| Lymphocytes (per mm3) | 510 | 370 | 110 | |
| Platelets (per mm3) | 295,000 | 353,000 | 5000 | |
| Hemoglobin (gr/dL) | 8.7 | 11.7 | 8.4 | |
| Prothrombin time (second) | 17 | 11.4 | 11.2 | |
| Activated thromboplastin time (second) | 26 | 26.8 | 27.2 | |
| Fibrinogen (mg/dL) | 199–400 | 332 | 473 | 406 |
| D-dimer -ng/ml | 100–560 | 800 | 1700 | 1200 |
| Antithrombin III (U/mL) | 0.90–1.30 | 0.98 | 1.25 | 0.99 |
| Lactic dehydrogenase | 110–295 | 717 | 482 | 301 |
| Interleukin (6 pg/mL) | 0–5.9 | 41 | - | - |
| Ferritin (ng/mL) | 7–140 | 2092 | 2366 | 2190 |
| Procalcitonin (ng/mL) | < 0.5 | 0.27 | 0.05 | 0.17 |
| C-reactive protein (mg/L) | 1.3 | 500.4 | 110 | |
| Antibiotics | Clarithromycin | Clarithromycin | Clarithromycin | |
| Thromboprophylaxis | Enoxaparin | Enoxaparin | No | |
| Survived | Yes | Yes | No | |
| Days of hospital stay | 14 | 13 | 1 | |