Table 4C.

Multivariate analysis of PFS by tumor histology subtype compared to PUC, with Bellmunt covariates

PUC vs. VUC	HR (95% CI)	p value
Variant UC	0.92 (0.70 – 1.21)	0.56
Age	0.98 (0.97-1.00)	0.01
Hgb	1.01 (0.94 – 1.08)	0.81
Liver Metastasis	1.85 (1.36 – 2.50)	<0.001
Albumin	0.58 (0.44 – 0.77)	<0.001
ECOG PS 0	Reference	reference
ECOG PS 1	1.19 (0.87 – 1.62)	0.29
ECOG PS 2	1.26 (0.86 – 1.84)	0.24
ECOG PS 3	2.02 (0.98 – 4.15)	0.06
Variant UC	0.91 (0.70 – 1.19)	0.50
Bellmunt 0	reference	reference
Bellmunt 1	1.37 (0.97 – 1.95)	0.08
Bellmunt 2	2.02 (1.40 – 2.93)	<0.001
Bellmunt 3	3.09 (1.70 – 5.60)	<0.001
Pure UC vs. NE	HR (95% CI)	p value
Neuroendocrine	1.57 (0.75 – 3.29)	0.24
Age	0.98 (0.97 – 0.99)	0.003
Hgb	1.05 (0.97 – 1.13)	0.24
Liver Metastasis	2.04 (1.44 – 2.89)	<0.001
Albumin	0.55 (0.40 – 0.76)	<0.001
ECOG PS 0	reference	reference
ECOG PS 1	1.00 (0.69 – 1.42)	0.97
ECOG PS 2	1.11 (0.72 – 1.70)	0.65
ECOG PS 3	1.88 (0.90 – 3.93)	0.09
Neuroendocrine	1.67 (0.78 – 3.55)	0.18
Bellmunt 0	reference	reference
Bellmunt 1	1.14 (0.76 - 1.71)	0.52
Bellmunt 2	1.86 (1.20 – 2.87)	0.01
Bellmunt 3	2.30 (1.17 – 4.54)	0.02

Cox hazard ratio (HR) was calculated to compare OS of patients with pure urothelial cancer versus each histology subtype (VUC as defined previously, or each variant histology).

Abbreviations: Hgb, hemoglobin; ECOG, Eastern Cooperative Oncology Group; NE, neuroendocrine; PS, performance status; PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma