Table 2C.

Multivariate analysis of observed ORR by tumor histology subtype compared to PUC, utilizing two separate models with significant covariates

PUC vs. VUC	OR (95% CI)	p value
VUC	1.08 (0.66 - 1.77)	0.75
Age	1.03 (1.01 - 1.06)	0.007
Hgb	1.07 (0.93 - 1.22)	0.33
Albumin	1.47 (0.90 - 2.42)	0.13
VUC	1.07 (0.66 – 1.74)	0.77
Bellmunt 0	reference	reference
Bellmunt 1	1.36 (0.73 - 2.52)	0.33
Bellmunt 2	0.90 (0.45 - 1.79)	0.75
Bellmunt 3	0.60 (0.15 - 2.33)	0.46
PUC vs NE	OR (95% CI)	p value
NE	0.75 (0.15 - 3.88)	0.73
Age	1.04 (1.01 - 1.06)	0.01
Hgb	1.10 (0.94 - 1.29)	0.21
Albumin	1.37 (0.77 – 2.44)	0.29
NE	0.89 (0.17 – 4.69)	0.89
Bellmunt 0	reference	reference
Bellmunt 1	1.69 (0.77 - 3.68)	0.19
Bellmunt 2	1.09 (0.45 - 2.64)	0.85
Bellmunt 3	0.57 (0.11 – 3.04)	0.51

Logistic regression odds ratio (OR) was calculated to compare ORR of patients with PUC versus histology subtype (VUC or NE).

Subsequent therapy = patients received ICI during 2^nd and beyond line therapy.

Abbreviations: Hgb, hemoglobin; NE, neuroendocrine; PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma