Table 3B.

Overall survival (OS) by tumor histology subtype, per treatment line or primary tumor site

OS, months (95% CI)	PUC	Variant UC	HR (95% CI) vs. PUC	p value
First line (n = 211; 142 PUC, 69 VUC)	13.3 (10.2-20.6)	10.1 (6.8 -16.8)	1.22 (0.84-1.77)	0.30
Subsequent (n = 195; 144 PUC, 51 VUC)	9.2 (7.7-11.4)	10.9 (4.6 -19.0)	0.95 (0.64-1.42)	0.81
Upper tract (n= 57; 39 PUC, 18 VUC)	14 (10-28)	4 (2-19)	2.18 (1.10-4.32)	0.03
Lower tract (n= 330; 233 PUC, 97 VUC)	9 (7-13)	11 (7-19)	0.94 (0.69-1.28)	0.07

PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma