Table 3C.
Multivariate analysis of observed OS by tumor histology subtype (VUC or NE) compared to PUC, utilizing two distinct models
| PUC vs. VUC | HR (95% CI) | p value |
|---|---|---|
| VUC | 1.07 (0.81 – 1.43) | 0.62 |
| Hgb | 0.96 (0.89 – 1.04) | 0.32 |
| Liver Metastasis | 1.67 (1.22 – 2.29) | 0.001 |
| Albumin | 0.45 (0.34 – 0.60) | <0.001 |
| ECOG PS 0 | reference | reference |
| ECOG PS 1 | 1.26 (0.89 – 1.77) | 0.20 |
| ECOG PS 2 | 1.36 (0.91 – 2.04) | 0.14 |
| ECOG PS 3 | 2.13 (0.94 – 4.80) | 0.07 |
| VUC | 1.12 (0.85 – 1.58) | 0.41 |
| Bellmunt 0 | reference | reference |
| Bellmunt 1 | 1.79 (1.19 – 2.69) | 0.005 |
| Bellmunt 2 | 2.90 (1.90 – 4.45) | <0.001 |
| Bellmunt 3 | 4.27 (2.25 – 8.11) | <0.001 |
| PUC vs. NE | HR (95% CI) | p value |
| NE | 2.11 (1.06 – 4.19) | 0.03 |
| Hgb | 1.01 (0.92 – 1.09) | 0.90 |
| Liver Metastasis | 1.80 (1.25 – 2.60) | 0.001 |
| Albumin | 0.41 (0.30 – 0.57) | <0.001 |
| ECOG PS 0 | Reference | reference |
| ECOG PS 1 | 1.01 (0.68 – 1.48) | 0.98 |
| ECOG PS 2 | 1.03 (0.65 – 1.64) | 0.90 |
| ECOG PS 3 | 1.79 (0.74 – 4.34) | 0.19 |
| NE | 3.76 (1.36 – 5.59) | 0.005 |
| Bellmunt 0 | reference | reference |
| Bellmunt 1 | 1.29 (0.82 – 2.05) | 0.27 |
| Bellmunt 2 | 2.32 (1.42 – 3.80) | 0.001 |
| Bellmunt 3 | 2.75 (1.35 – 5.58) | 0.005 |
Cox hazard ratio (HR) was calculated to compare OS of patients with pure urothelial cancer versus each histology subtype (VUC as defined previously, or each variant histology).
Subsequent therapy = patients received ICI during 2nd and beyond line therapy.
Abbreviations: Hgb, hemoglobin; ECOG, Eastern Cooperative Oncology Group; PS, performance status, NR, not reached; NE, neuroendocrine; PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma.