Table 4A.

Progression-free survival (PFS) by tumor histology subtype

	N	PFS, months (95% CI)	HR (95% CI) vs. PUC	p value
PUC	284	4.1 (3.5 – 5.0)
VUC	119	5.2 (3.0 - 7.6)	0.90 (0.70 -1.17)	0.43
Squamous	51	4.1 (2.1 - 7.5)	1.00 (0.70- 1.44)	0.99
Micropapillary	26	7.6 (2.1 - 21.4)	0.71 (0.43 - 1.19)	0.20
Sarcomatoid	16	10.3 (1.6 - 18.6)	0.92 (0.50 – 1.70)	0.80
Plasmacytoid	11	5.9 (1.0 – NR)	0.99 (0.49 - 2.01)	0.98
Adenocarcinoma	10	7.6 (1.2 - NR)	0.57 (0.25 - 1.27)	0.17
NE	9	3.7 (0.3 - 6.3)	1.87 (0.92 - 3.79)	0.09
		PFS, months (95% CI)	HR (95% CI) vs. VUC w/o NE	p value
VUC without NE	110	5.9 (3.0 - 8.5)
NE	9	3.7 (0.3 - 6.3)	2.24 (1.07 - 4.69)	0.03

NE: Neuroendocrine; UC: urothelial carcinoma; PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma