Table 4B.

Progression-free survival (PFS) by tumor histology subtype, per treatment line or primary tumor site

PFS, months (95% CI)	PUC	VUC	HR (95% CI) vs. PUC	p value
First line (n= 209)	4.2 (3.1 – 6.2)	5.9 (2.7 – 9.3)	0.92 (0.65-1.30)	0.62
Subsequent (n = 194)	4.1 (3.5 - 5.5)	5.2 (2.8 – 8.5)	0.90 (0.61-1.33)	0.60
Upper tract (n= 57; 39 PUC, 18 VUC)	4 (2-7)	2 (1-5)	1.33 (0.70-2.50)	0.38
Lower tract (n= 327; 231 PUC, 96 VUC)	4 (3-6)	6 (4-10)	0.84 (0.63-1.12)	0.23

PUC, pure urothelial carcinoma; VUC, variant urothelial carcinoma