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Biphasic synovial sarcoma with intermixed glandular and spindle cell components (A) and monophasic synovial sarcoma consisting of spindle cells arranged in fascicles with prominent wiry collagen (B). The SS18-SSX fusion-specific antibody (E9X9V) reveals strong diffuse nuclear positivity in both cases (C and D), including in the glandular component of biphasic synovial sarcoma. The SSX C-terminus antibody (E5A2C) is likewise strongly and diffusely positive in both cases (E and F).
