Table 4.
Association FGF-23 with Incident Hypertension
| N | # with incident HTN | incidence rate | Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|---|---|---|
| (%/yr) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| FGF-23 (per 2 fold higher) | 1109 | 576 | 7.82 | 1.23 (1.08, 1.39) | 1.21 (1.07, 1.38) | 1.18 (1.03, 1.35) | 1.18 (1.03, 1.36) |
| FGF-23 Quartiles | |||||||
| < 36 | 350 | 166 | 6.62 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 36 -- 46 | 313 | 152 | 6.98 | 1.08 (0.86, 1.35) | 1.05 (0.84, 1.32) | 1.04 (0.83, 1.30) | 1.04 (0.83, 1.31) |
| 47 -- 60 | 259 | 138 | 8.38 | 1.23 (0.97, 1.54) | 1.20 (0.95, 1.52) | 1.17 (0.92, 1.48) | 1.17 (0.92, 1.49) |
| > 60 | 187 | 120 | 11.61 | 1.80 (1.42, 2.29) | 1.78 (1.40, 2.26) | 1.67 (1.31, 2.14) | 1.69 (1.31, 2.18) |
Model 1 = unadjusted analysis.
Model 2 = adjusted for age, sex, and race
Model 3 = M2 + diabetes, cardiovascular disease, eGFR UACR, BMI, and smoking.
Model 4 = M3 + calcium, phosphorus, 25(OH) Vitamin D and PTH