Table 5.
Association of FGF-23 with systolic and diastolic blood pressure trajectories
| Annualized absolute change in SBP | |||||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| N | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | |
| FGF-23 (per 2 fold higher) | 2785 | 0.14 (−0.01, 0.29) | 0.16 (0.01, 0.31) | 0.20 (0.05, 0.35) | 0.24 (0.08, 0.40) |
| FGF-23 Quartiles | |||||
| < 36 | 697 | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) |
| 36 -- 46 | 696 | −0.10 (−0.35, 0.15) | −0.09 (−0.34, 0.16) | −0.09 (−0.34, 0.16) | −0.07 (−0.32, 0.19) |
| 47 -- 60 | 696 | 0.05 (−0.20, 0.31) | 0.10 (−0.15, 0.36) | 0.10 (−0.16, 0.36) | 0.16 (−0.10, 0.42) |
| > 60 | 696 | 0.11 (−0.15, 0.37) | 0.14 (−0.12, 0.40) | 0.21 (−0.06, 0.48) | 0.30 (0.02, 0.58) |
| Annualized absolute change in DBP | |||||
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| FGF-23 (per 2 fold higher) | 2785 | 0.00 (−0.08, 0.08) | 0.00 (−0.07, 0.08) | 0.02 (−0.06, 0.10) | 0.04 (−0.04, 0.12) |
| FGF-23 Quartiles | |||||
| < 36 | 697 | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) |
| 36 -- 46 | 696 | −0.06 (−0.19, 0.08) | −0.06 (−0.19, 0.07) | −0.07 (−0.20, 0.06) | −0.06 (−0.19, 0.07) |
| 47 -- 60 | 696 | −0.06 (−0.19, 0.07) | −0.05 (−0.19, 0.08) | −0.05 (−0.19, 0.08) | −0.01 (−0.15, 0.12) |
| > 60 | 696 | −0.01 (−0.14, 0.13) | −0.01 (−0.14, 0.13) | 0.04 (−0.10, 0.18) | 0.09 (−0.06, 0.23) |
Model 1 = unadjusted analysis.
Model 2 = adjusted for age, sex, and race
Model 3 = M2 + diabetes, cardiovascular disease, eGFR, UACR, BMI, and smoking
Model 4 = M3 + calcium, phosphorus, 25(OH) Vitamin D and PTH