Table 2. Univariate and Multivariate Analyses for 3-Year Post-Recurrence Survival.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age at diagnosis, years | ||||
| < 50* | ||||
| ≥ 50 | 1.57 (0.80–3.06) | 0.187 | ||
| Sex | ||||
| Male* | ||||
| Female | 0.54 (0.27–1.09) | 0.086 | ||
| Type of gastrectomy | ||||
| Total* | ||||
| Subtotal | 0.69 (0.35–1.36) | 0.282 | ||
| Pathologic T stage† | ||||
| T1* | ||||
| T2 | 1.35 (0.32–5.71) | 0.682 | ||
| T3 | 0.86 (0.21–3.61) | 0.837 | ||
| T4 | 1.77 (0.53–5.89) | 0.355 | ||
| Pathologic N stage† | ||||
| N0* | ||||
| N1 | 0.78 (0.17–3.69) | 0.754 | ||
| N2 | 2.39 (0.79–7.13) | 0.119 | ||
| N3 | 2.01 (0.89–4.51) | 0.091 | ||
| TNM stage† | ||||
| I* | ||||
| II | 0.95 (0.26–3.53) | 0.942 | ||
| III | 1.79 (0.54–5.97) | 0.337 | ||
| Histopathologic subtype | ||||
| Adenocarcinoma* | ||||
| Signet ring cell | 1.26 (0.65–2.43) | 0.493 | ||
| Lauren histotype | ||||
| Diffuse* | ||||
| Intestinal | 0.68 (0.33–1.41) | 0.298 | ||
| LNR | ||||
| ≤ 0.063* | ||||
| > 0.063 | 2.22 (1.12–4.43) | 0.023 | ||
| SUVmax | ||||
| ≤ 5.1* | ||||
| > 5.1 | 3.30 (1.58–6.87) | 0.001 | 2.57 (1.16–5.69) | 0.012 |
| Weight loss, % | ||||
| ≤ 14.7* | ||||
| > 14.7 | 2.91 (1.48–5.71) | 0.002 | 2.24 (1.11–4.56) | 0.025 |
| Hemoglobin, g/dL | ||||
| ≥ 11.4* | ||||
| < 11.4 | 1.88 (0.98–3.58) | 0.055 | ||
| Neutrophil count, cells/uL | ||||
| ≤ 2997* | ||||
| > 2997 | 2.89 (1.45–5.79) | 0.003 | 2.68 (1.32–5.43) | 0.006 |
| Lymphocyte count, cells/uL | ||||
| ≤ 1084* | ||||
| > 1084 | 0.58 (0.30–1.10) | 0.095 | ||
| Platelet count, cells/uL | ||||
| ≥ 154000* | ||||
| < 154000 | 2.16 (0.88–5.31) | 0.094 | ||
| Recurrence timing | ||||
| Early, ≤ 2 years | 2.40 (1.18–4.91) | 0.016 | ||
| Late, > 2 years* | ||||
| First sites of recurrence | ||||
| Locoregional recurrence only* | ||||
| Distant metastasis only | 1.49 (0.52–4.31) | 0.458 | ||
| Locoregional and distant failure | 2.62 (0.81–8.41) | 0.107 | ||
*Reference of categorical parameter, †According to 8th AJCC staging system. CI = confidence interval, HR = hazard ratio