Table 1. Query for Literature Database Search.
| PICO | Query for Issues 1 and 2 | Query for Issue 3 | ||
|---|---|---|---|---|
| Search Concept | Search Term | Search Concept | Search Term | |
| P: A AND B AND C | A. Patient with rectal cancer: #1 OR #2 | #1: “Rectal Neoplasms”[Mesh] | A. Patient with rectal cancer: #1 OR #2 | #1: “Rectal Neoplasms”[Mesh] |
| #2: (Colorectal[TW] OR Rectal[TW] OR rectum[TW] OR Anus[TW]) AND (Neoplasm*[TW] OR neoplasia[TW] OR cancer*[TW] OR tumor*[TW] OR tumour*[TW] OR Carcinoma*[TW] OR Malignan*[TW]) | #2: (Colorectal[TW] OR Rectal[TW] OR rectum[TW] OR Anus[TW]) AND (Neoplasm*[TW] OR neoplasia[TW] OR cancer*[TW] OR tumor*[TW] OR tumour*[TW] OR Carcinoma*[TW] OR Malignan*[TW]) | |||
| B. Undergoing chemoradiation therapy: #3 OR #4 OR #5 OR #6 | #3: “Chemoradiotherapy”[Mesh] | B. Undergoing chemoradiation therapy: #3 OR #4 OR #5 OR #6 | #3: “Chemoradiotherapy”[Mesh] | |
| #4: chemoradiotherap*[TW] OR chemoradiation*[TW] OR radiochemotherap*[TW] OR chemo-rad*[TW] OR Radio-Chemo*[TW] OR “CCRT”[TW] OR “CCRTx”[TW] | #4: chemoradiotherap*[TW] OR chemoradiation*[TW] OR radiochemotherap*[TW] OR chemo-rad*[TW] OR Radio- Chemo*[TW] OR “CCRT”[TW] OR “CCRTx”[TW] | |||
| #5: chemotherap*[TW] AND (radiation therap*[TW] OR Radiotherap*[TW]) | #5: chemotherap*[TW] AND (radiation therap*[TW] OR Radiotherap*[TW]) | |||
| #6: “Neoadjuvant Therapy”[Mesh] OR neoadjuvant*[TW] | #6: “Neoadjuvant Therapy”[Mesh] OR neoadjuvant*[TW] | |||
| C. Pathologic complete response to therapy: #7 OR #8 | #7: Basic terms: complete respon*[TW] OR complete remission*[TW] | C. Managed by watch and wait approach after therapy: #14 | #14: “Watchful Waiting”[Mesh] OR “Watch and wait”[TW] OR “Wait-and-see”[TW] OR “Watch & Wait”[TW] | |
| #8: Additional terms to expand the search: completed respon*[TW] OR pathologic respon*[TW] OR Clinical respon*[TW] OR “tumour regression grade”[TW] OR “tumor regression grade”[TW] OR “tumour regression grades”[TW] OR “tumor regression grades”[TW] OR viable[TW] | ||||
| I and C | MRI or other typical tests (endoscopy, endorectal ultrasound, CT, or PET): #9 OR #10 OR #11 OR #12 OR #13 | #9: Basic terms: Magnetic Resonance Imaging[Mesh] OR Magnetic Resonanc*[TW] OR MRI[TW] OR MRIs[TW] OR MR[TW] | Not applicable | Not applicable |
| #10: Additional terms to expand the search: “diffusion-weighted”[TW] OR “DWI”[TW] OR “T2-weighted”[TW] | ||||
| #11: “Colonoscopy”[Mesh] OR colonoscop*[TW]OR Endoscop*[TW] OR Ultrasound*[TW] OR ultrasonograp*[TW] OR EUS[TW] OR Endosonography[Mesh] OR Endosonograp*[TW] | ||||
| #12: “Tomography, X-Ray Computed”[Mesh] OR CT[TI] OR Computed tomograp*[TW] OR computer assisted tomograp*[TW] OR computerised tomograp*[TW] | ||||
| #13: “Positron-Emission Tomography”[Mesh] OR “Positron-Emission”[TW] OR PET[TW] | ||||
| O | Not applied, i.e., hand search of relevant articles | Not applicable | ||
| Others | Written in English | #15: English[Lang] | Written in English | #15: English[Lang] |
| Final search query | P AND (I and C) AND Others | P AND Others | ||
Table shows search query for PubMed MEDLINE. Search in EMBASE and Cochrane Library was performed using same search queries except for minor modifications related to differences in design of three databases. We additionally limited EMBASE search to article, article in press, and review by adding “AND (‘article’/it OR ‘article in press’/it OR ‘review’/it)” to query for more effective search as EMBASE includes a lot more conference abstracts/proceedings than PubMed MEDLINE. We could not use language restriction to English (#15) for Cochrane Library as it did not have this functionality. CT = computed tomography, PET = positron-emission tomography