Table 2. Studies Reporting Sensitivity and Specificity for Diagnosing pCR both for T2 and for Combined T2 and DWI in Same Group of Patients.

First Author (Year)	Study Type	MR Method	Sensitivity, %*	Specificity, %*	Comparative Result	Method to Combine T2 and DWI Results
Kim (2009) (31)	Retrospective	T2	54.5 (6/11)	75.9 (22/29)	Significantly higher overall accuracy for combined T2 and DWI compared with T2 (p = 0.0313 by McNemar test)	T2 findings as primary results, with DWI to override T2 when T2 findings are equivocal or to increase reader confidence if T2 and DWI findings are consistent
		Combined T2 and DWI	90.9 (10/11)	82.8 (24/29)
Lambregts (2011) (34)	Retrospective	T2	40.0 (10/25)	91.6 (87/95)	No statistical comparisons regarding binary interpretations. Area under ROC curve was 0.8 for combined T2 and DWI and 0.76 for T2 (p = 0.39)	Obscure
		Combined T2 and DWI	56.0 (14/25)	93.7 (89/95)
Sassen (2013 (40)	Retrospective	T2	30.0 (3/10)	86.7 (52/60)	No statistical comparisons regarding binary interpretations. Area under ROC curve was 0.89 for combined T2 and DWI and 0.77 for T2 (p = 0.005)	Obscure
		Combined T2 and DWI	70.0 (56/60)	93.3 (56/60)
Horvat (2018) (28)	Retrospective	T2	57.1 (12/21)	73.1 (68/93)	No statistical comparisons	Obscure†
		Combined T2 and DWI	84.2 (16/19)	56.3 (49/87)
Meta-analytic summary	NA	T2	47 (95% CI, 30–63)	84 (95% CI, 72–95)	p = 0.01 from joint-model bivariate meta-regression analysis	NA
		Combined T2 and DWI	74 (95% CI, 60–88)	85 (95% CI, 74–96)

^*Numbers in parentheses are number of patients unless specified otherwise, ^†Article states complete tumor response on MRI when both T2 and DWI were negative for residual tumor. However, reported results are more compatible with combined MRI result of complete tumor response when T2 or DWI was negative for residual tumor. CI = confidence interval, DWI = diffusion-weighted imaging, MR = magnetic resonance, NA = not applicable, pCR = pathologic complete response, ROC = receiver operating characteristic, T2 = T2-weighted imaging