Fig. 2.

(1): A Photomicrograph of a section showing the normal control cerebral cortex of adult rats with the molecular layer containing nuclei of neuroglial cells, the granular layer containing numerous granular cells with rounded open face nuclei (black arrow) and small pyramidal cells with short apical dendrites (blue arrow) (H&E×400). (2): A Photomicrograph of a section of cerebral cortex of the donepezil (0.75 mg/kg) treated rats showing nearly normal neuronal cells (H&E×400). (3): A Photomicrograph of the cerebral cortex of the AlCl₃ treated rats showing cellular vascular degeneration, atrophy, pyknosis, necrosis, neurology, congestion of cerebral blood vessels and focal cerebral haemorrhage (H&E×400). (4): Photomicrograph of the cortex of rat treated with low dose of limonoid showing marked improvement in most of the granule cells while the pyramidal are shown to be irregular in shape and surrounded by pericellular halos (H&E ×400). (5): A Photomicrograph of the cortex of rats treated with high dose of limonoid showing prominent regeneration where molecular layer contain nuclei of neuroglia cells and are covered with pia mater, and the granular layer contains numerous granular cells with rounded open face nuclei (H&E ×400).(6): A Photomicrograph of the cortex of rats treated with a low dose of hesperidin showing more or less improvement in granular cells and focal celluar pyknosis (H&E×400).(7): A Photomicrograph of the cortex of rats treated with a high dose of hesperidin showing nearly normal granular cells and neural structure (H&E ×400).