Table 2.
Effect of hesperidin (125 and 250 mg/kg) and limonoids (50 and100 mg/kg) on psychological state of AD induced rats tested by open field test.
| Group |
Negative control (2 mL distilled water) | Positive control AlCl3 (172 mg/kg) | Donepezil (0.75 mg/kg) | Hesperidin (125 mg/kg) | Hesperidin (250 mg/kg) | Limonoids (50 mg/kg) | Limonoids (100 mg/kg) | |
|---|---|---|---|---|---|---|---|---|
| Open Field Test | ||||||||
| Ambulation | Frequency | 195+9.57 | 62.5+3.22@ | 83.33+3.33@ | 106.7+3.33@*#& | 96.67+1.66@*#& | 53.33+3.33@$& | 143.3+6.66@*$ |
| % fromnegative control | ------- | 32.05 | 42.73 | 54.71 | 49.57 | 27.34 | 73.48 | |
| Rearing | Frequency | 17.75+0.85 | 5.5+0.64@ | 8.5+0.28@* | 4.33+0.33@$& | 5.33+0.33@$& | 4+0.57@$& | 8.66+0.33@* |
| % from negative control | ------- | 30.98 | 47.88 | 24.39 | 30.02 | 22.53 | 48.78 | |
Results are expressed as means ± SE, n = 10. significance at p < 0.05.@ Significantly different from normal control, *Significantly different from positive control group.$ Significantly different from donepezil (0.75 mg/kg) group. # Significantly different from limonoids (50 mg/kg) group& Significantly different from limonoids (100 mg/kg) group.